Hydrazinium chloride → HCID 178469379, Verbindung

HRID 33269

Reaktionsgleichung

Reaktionsgleichung von HRID 33269
[Na].[C:2]([O:12][CH2:13][CH3:14])(=[O:11])[CH2:3][C:4]([C:6](OCC)=[O:7])=O.Cl.[NH2:16][NH2:17]>C(O)C.O.Cl>[CH2:13]([O:12][C:2]([C:3]1[NH:16][N:17]=[C:6]([OH:7])[CH:4]=1)=[O:11])[CH3:14]

Komponenten

6

Edukt 2

HCID 115031Hydrazinium chlorideHCID 57351814Diethyl 2-oxosuccinate,sodium salt

Produkt 1

HCID 178469379HCID 178469379, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 5 g Diethyl Oxalacetate sodium salt in 100 ml ethanol, 1.5 g hydrazine monohydrochloride were added and the reaction mixture was heated to 80° C. for 3 h. Then the solution was diluted with 100 ml of water containing 3 ml of halfconcentrated HCl and extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was subjected to the next reaction step without further purification; Yield: 3.4 g

Aufarbeitung

  1. extractionextracted with DCM (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude product was subjected to the next reaction step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-1eaec0aabaf74bf68499db6ce002e679
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429581B2

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