Hydrochloric Acid → HCID 18934769, Verbindung

HRID 3328

Reaktionsgleichung

Reaktionsgleichung von HRID 3328
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8].Cl>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 189347597a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

Produkt 1

HCID 18934769HCID 18934769, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (35 mg, 74%): mp 181°-183° C.; 1H NMR (D2O, 300 MHz) δ2.15-2.50 (m, 6H), 2.56-2.65 2H), 3.34-3.42 (m, 2H), 3.79-3.87 (m, 2H), 8.24-8.29 (m, 2H); MS (CI/NH3) m/z: 241 (M+H)+ ; MS (CI/NH3): m/z 241/243 (M+H+). Anal. Calcd for C12H14 ClFN2.HCl: C, 52.00; H, 5.45; N, 10.11. Found: C, 51.81; H, 5.62; N, 9.84.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe solid was triturated with Et2O
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-de9abf64e74b42648268c346ed5db6f3
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733912

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