HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3,5-Dichloropyrazine-2-carbonitrile | HCID 52987744 | — |
| Edukt | (R)-2-Amino-4-methylpentanamide hydrochloride | HCID 56776963 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Lösungsmittel | 2-Oxopropiononitrile | HCID 69430 | — |
| Produkt | (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide | HCID 86685528 | 98,3% |
Reaktionsschritte
To a mixture of 3,5-dichloropyrazine-2-carbonitrile (100 mg, 0.57 mmol) and D-leucinamide HCl salt (104 mg, 0.625 mmol) in AcCN (2 mL) was added DIPEA (0.223 mL, 1.254 mmol). After stirring at room temperature for 4 h, it was diluted with EtOAc, washed with sat. NaHCO3, organic layer was separated and washed with brine, dried and concentrated to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide (150 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877760B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-7ef5cb17d84541df92deb0695a21a903 |
| Quellennotiz | uspto-grants-2014_11 |