1,1'-Biphenyl, 3-nitro- → 3-Aminobiphenyl

HRID 333545

Reaktionsgleichung

Reaktionsgleichung von HRID 333545
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].C(O)C>[C:6]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=[C:4]([NH2:1])[CH:5]=1

Komponenten

4

Edukt 1

HCID 164501,1'-Biphenyl, 3-nitro-

Produkt 1

HCID 167173-Aminobiphenyl

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Palladium on carbon (10%, 0.70 g, 0.658 mmol) was added to a Parr hydrogenator bottle. The bottle was purged with nitrogen. Next, 3-nitro-1,1′-biphenyl (10 g, 50.2 mmol) and 190 mL ethanol were added to the bottle. The material was hydrogenated on a Parr hydrogenator. After 3 h, the reaction mixture was filtered through Celite® and the Celite® washed with dichloromethane. The filtrate was evaporated, obtained a brown oil, 8.69 g, assume quantitative yield (8.49 g).

Aufarbeitung

  1. customThe bottle was purged with nitrogen
  2. filtrationthe reaction mixture was filtered through Celite®
  3. washthe Celite® washed with dichloromethane
  4. customThe filtrate was evaporated
  5. customobtained a brown oil, 8.69 g

Quellen und Nachweise

ORD-Eintrag
ord-53480da2aa694c0bb79d3511b42f4bce
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883322B2

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