Ethanol → 2-Ethylamino-3-nitropyridine
Reaktionsgleichung
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12].C(O)C>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]Komponenten
4
Versuchsvorschrift
2-Chloro-3-nitropyridine (20.00 g, 126 mmol) was added to ethylamine in ethanol (40 mL, 80 mmol) at room temperature and kept overnight. The solution was evaporated, the residue was diluted with 150 mL of EtOAc, washed with aqueous NaHCO3 and purified by column chromatography on silica gel (hexane/ethyl acetate 4/1) to give yellow solid (19.5 g, 92%).
Aufarbeitung
- customThe solution was evaporated
- additionthe residue was diluted with 150 mL of EtOAc
- washwashed with aqueous NaHCO3
- custompurified by column chromatography on silica gel (hexane/ethyl acetate 4/1)
Quellen und Nachweise
- ORD-Eintrag
- ord-73ac23f5c8694659b3474991d37be063
- Quelldatensatz
- uspto-grants-2014_11
- Patentnummer
- US08883322B2
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