Hydrochloric Acid → HCID 178462804, Verbindung

HRID 333552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333552
[CH2:1]([NH:3][C:4]1[C:9]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)C.[ClH:17].C(O[CH2:26][CH3:27])(OCC)OCC>C(O)=O>[Cl:17][N+:3]1([CH2:26][CH3:27])[C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH-:1]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 31214Ethyl orthoformateHCID 70665410HCID 70665410, Verbindung

Produkt 1

HCID 178462804HCID 178462804, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

N2-ethyl-N3-phenylpyridine-2,3-diamine (8.5 g, 40 mmol), concentrated HCl (6 mL), and 4 mL of formic acid were added to the triethyl orthoformate (376 mL). The reaction was refluxed overnight. After it cooled to room temperature, the beige solid was collected by filtration. The solid was further purified by recrystallizing from ethanol to give 3-chloro-3-ethyl-1-phenyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-3-ium-2-ide (9.4 g, 91% yield).

Aufarbeitung

  1. temperatureThe reaction was refluxed overnight
  2. filtrationthe beige solid was collected by filtration
  3. customThe solid was further purified
  4. customby recrystallizing from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e6aa036cc27a441ca968d25f2050ce80
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883322B2

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