Sodium Methoxide → tert-Butyl 4-(5-methoxy-pyrazolo[1,5-a]pyrimidin-7-yl)piperazine-1-carboxylate
Reaktionsgleichung
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[N:5]2[N:21]=[CH:22][CH:23]=[C:4]2[N:3]=1.[CH3:24][O-:25].[Na+]>CO>[CH3:24][O:25][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[N:5]2[N:21]=[CH:22][CH:23]=[C:4]2[N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
tert-Butyl 4-(5-chloro-pyrazolo[1,5-a]pyrimidin-7-yl)piperazine-1-carboxylate (1.23 g, 3.65 mmol) was dissolved under an argon atmosphere in anhydrous methanol (6 ml). Sodium methanolat (3.65 ml of a 1M solution in methanol) was added and the mixture was heated under reflux for 9 hours. The solvent was removed under reduced pressure, the residue taken up in dichloromethane, the resulting solution was washed with water, dried over magnesium sulfate, the solvent removed under reduced pressure to yield 1.186 g of a solid (3.56 mmol, 98%). MS (APCI): m/z=334.3 [M+1]+.