[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH:5]1[N:10]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[C:13]([CH3:21])[CH:12]=2)[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.Cl>O1CCOCC1.C(OCC)C>[CH3:21][C:13]1[CH:12]=[C:11]([N:10]2[CH2:9][CH2:8][NH:7][CH2:6][CH:5]2[CH2:4][C:3]([O:2][CH3:1])=[O:29])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1tert-Butyl 3-(2-methoxy-2-oxo-ethyl)-4-(2-methyl-4-quinolyl)piperazine-1-carboxylate (239 mg, 0.28 mmol) was dissolved in dioxane (1 ml), combined with a solution of HCl in dioxane (4N, 4 ml, 16 mmol) and stirred overnight. The mixture was diluted with diethylether, the precipitate was collected by filtration and dissolved in DCM. The solution was washed with a saturated solution of sodium bicarbonate and dried over sodium sulfate. The solvent was removed under reduced pressure, the residue was triturated with diethylether to yield 85 mg of a yellow solid (0.253 mmol, 72%).
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