Sodium Hydroxide → 1-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HRID 334009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334009
C[O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.O>[Cl:16][C:12]1[CH:11]=[C:10]([N:7]2[CH:8]=[N:9][C:5]([C:3]([OH:4])=[O:2])=[N:6]2)[CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 694601791-(3-chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

Produkt 1

HCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

14.8 g (62.3 mmol) 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester was taken up in 70 mL THF and treated with 40 mL 4M aqueous NaOH solution at RT for 12 h. The reaction mixture was diluted with water, THF was removed by distillation, ice water was added and the mixture was acidified with 4 M aqueous HCl solution. The precipitated was filtered off, washed with water and triturated with diethyl ether.

Aufarbeitung

  1. customwas removed by distillation, ice water
  2. additionwas added
  3. filtrationThe precipitated was filtered off
  4. washwashed with water
  5. customtriturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-e4d67e829e2d4b528419bf968f0a800a
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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