HCID 86688251, Verbindung → (3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

HRID 334021Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334021
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13][C:12]1([CH3:28])[CH3:27])=O)C1C=CC=CC=1>[Pd].CO>[CH3:27][C:12]1([CH3:28])[NH:11][CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13]1

Komponenten

4

Edukt 1

HCID 86688251HCID 86688251, Verbindung

Produkt 1

HCID 86688252(3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1.10 g (2.87 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester and 100 mg palladium on carbon in 20 mL methanol was hydrogenated at RT for 12 h at 3 bar. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a19f4a0946e746b6bbd57e8f9b6473e4
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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