Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334054

Reaktionsgleichung

Reaktionsgleichung von HRID 334054
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

Produkt 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d4a7b52437e44155b9cd4be82e8585e1
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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