(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone → (3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

HRID 334085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334085
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10][C:9]1([CH2:25][O:26][CH3:27])[CH3:24])C1C=CC=CC=1>[Pd].CO>[CH3:27][O:26][CH2:25][C:9]1([CH3:24])[NH:8][CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10]1

Komponenten

4

Edukt 1

HCID 86688307(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Produkt 1

HCID 86688308(3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 170 mg (414 μmol, purity: 90%) (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone and 20 mg palladium on carbon in 10 mL methanol was hydrogenated at 50° C. for 12 h at 50 psi. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1bd3ef443a624d2e966e9d99bac45393
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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