1-(2-Methoxyphenyl)piperazine → HCID 71678858, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[CH3:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]=O)[CH:23]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[CH3:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:12]2[CH2:13][CH2:14][N:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])[CH2:10][CH2:11]2)[CH:23]=1Komponenten
5
Versuchsvorschrift
77 mg of the target compound (0.21 mmol, 40.5%) was obtained using 1-(2-methoxyphenyl)piperazine (196 mg, 1.02 mmol), 2′-methylbiphenyl-3-carbaldehyde (100 mg, 0.51 mmol) and NaBH(OAc)3 (329 mg, 1.53 mmol) according to the synthesis method of Compound 1.