Acetone → 4-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine

HRID 33444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 33444
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=2)=[CH:4][CH:3]=1.O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]C(C)=O>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([S:18]([CH3:22])(=[O:20])=[O:17])[N:9]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 28211934-(4-Chlorophenyl)-2-(methylthio)pyrimidineHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 219059934-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of 4-(4-chlorophenyl)-2-methylthiopyrimidine (1.1 g, 4.65 mmol) in acetone (30 ml) and water (10 ml) was added oxone (7.14 g, 11.62 mmol). The reaction mixture was stirred for 18 hours then diluted with water and extracted into dichloromethane. The extracts were dried over magnesium sulfate, filtered and concentrated to provide a white solid: EI-MS (m/z) 269 [M+1]+.

Aufarbeitung

  1. extractionextracted into dichloromethane
  2. dry with materialThe extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customto provide a white solid

Quellen und Nachweise

ORD-Eintrag
ord-1833d5fec08f45d4815103b7e5e17d93
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429599B2

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