Dimethylformamide → Imidazo[1,2-a]pyridine-3-carbonyl Chloride

HRID 335333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 335333
[N:1]1[CH:2]=[C:3]([C:10]([OH:12])=O)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>C(Cl)Cl>[N:1]1[CH:2]=[C:3]([C:10]([Cl:16])=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 73142Imidazo(1,2-a)pyridine-3-carboxylic acid

Produkt 1

HCID 74890117Imidazo[1,2-a]pyridine-3-carbonyl Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A suspension of imidazo[1,2-a]pyridine-3-carboxylic acid (5.270 g, 32.5 mmol) in DCM (200 ml) was treated with oxalyl chloride (3.13 ml, 35.8 mmol) followed by the addition of DMF (0.252 ml, 3.25 mmol). The reaction mixture was stirred at RT overnight. The solvent was removed in vacuo to afford the title compound as a hydrochloride salt;

Aufarbeitung

  1. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-122103a473254fb99f822a83836a206f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883819B2

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