Diethyl Ether → HCID 50914394, Verbindung
Reaktionsgleichung
[C:1]([Li])([CH3:4])([CH3:3])[CH3:2].[CH3:6][C:7]1([CH3:12])[O:11][CH2:10][CH2:9][O:8]1.[S:13]([Cl:16])(Cl)=[O:14].CC[O:19]CC>>[CH3:6][C:7]1([CH3:12])[O:11][C@@H:10]([CH2:2][C:1]2([S:13]([Cl:16])(=[O:14])=[O:19])[CH2:4][CH2:3]2)[CH2:9][O:8]1Komponenten
5
Reaktionsbedingungen
- Temperatur
- -78 °C
Versuchsvorschrift
tert-Butyl lithium (2 eq) is added to a solution of (S)-4-(1-iodocyclopropyl)methyl)-2,2-dimethyl-1,3-dioxolane (1 eq) in ether at −78° C. and the mixture stirred at −78° C. for 30 mins. A solution of thionyl chloride in ether is added, the mixture warmed to room temperature and concentrated under reduced pressure. The residue is dissolved in chloroform, filtered and dried under reduced pressure.