Bromine → 2-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

HRID 335876

Reaktionsgleichung

Reaktionsgleichung von HRID 335876
[Br:1]Br.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[NH2:3][C:4]1[C:12]([F:13])=[CH:11][C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 5864082-Amino-3-fluorobenzoic acid

Produkt 1

HCID 673836892-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

Bromine (3.65 mL, 70.9 mmol) in Chloroform (250 mL) was added dropwise via an addition funnel to a suspension of 2-amino-3-fluorobenzoic acid (10 g, 64.5 mmol) in chloroform (400 mL) at RT. The solution was stirred for 12 hours at which point the resulting slurry was filtered. The solid was washed well with CH2Cl2 and dried under a stream of nitrogen to afford 2-amino-5-bromo-3-fluorobenzoic acid HBr.

Aufarbeitung

  1. filtrationwas filtered
  2. washThe solid was washed well with CH2Cl2
  3. customdried under a stream of nitrogen

Quellen und Nachweise

ORD-Eintrag
ord-61abd4bdca784578aa19294a8726b651
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883782B2

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