2-Methyl-3-butyn-2-ol → (S)-4-(2-amino-5'-fluoro-2'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthene]-7'-yl)-2-methylbut-3-yn-2-ol

HRID 336008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 336008
[NH2:1][C:2]1[O:3][CH2:4][C@@:5]2([N:22]=1)[C:18]1[CH:17]=[C:16](O)[CH:15]=[C:14]([F:20])[C:13]=1[O:12][C:11]1[C:6]2=[CH:7][C:8](Br)=[CH:9][CH:10]=1.[C:23]([C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[N:30][CH:31]=1)#[C:24][CH3:25].[CH3:35][C:36]([OH:40])([C:38]#[CH:39])[CH3:37]>>[NH2:1][C:2]1[O:3][CH2:4][C@:5]2([N:22]=1)[C:6]1[CH:7]=[C:8]([C:28]3[CH:29]=[N:30][CH:31]=[C:26]([C:23]#[C:24][CH3:25])[CH:27]=3)[CH:9]=[CH:10][C:11]=1[O:12][C:13]1[C:18]2=[CH:17][C:16]([C:39]#[C:38][C:36]([CH3:37])([OH:40])[CH3:35])=[CH:15][C:14]=1[F:20]

Komponenten

4

Edukt 3

HCID 82582-Methyl-3-butyn-2-olHCID 574164825-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride)HCID 58466133(S)-2-amino-7'-bromo-4'-fluoro-5H-spiro[oxazole-4,9'-xanthen]-2'-ol

Produkt 1

HCID 58466192(S)-4-(2-amino-5'-fluoro-2'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthene]-7'-yl)-2-methylbut-3-yn-2-ol

Versuchsvorschrift

The titled compound was synthesized by steps analogous to those described in method AA21 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[oxazole-4,9′-xanthen]-2′-ol (prepared by steps analogous to those described in Method BB40 and Example 2), 5-(prop-1-ynyl)pyridin-3-ylboronic acid, and 2-methylbut-3-yn-2-ol.

Aufarbeitung

  1. customprepared by steps analogous to

Quellen und Nachweise

ORD-Eintrag
ord-7832025272b64c15b6adc6f7e71e2af2
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883782B2

Notizen zur Reaktion

Wird geladen…