Tricalcium Phosphate → Alendronic Acid

HRID 336065

Reaktionsgleichung

Reaktionsgleichung von HRID 336065
P([O-])([O-])([O-])=O.[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[CH2:14]([CH2:26][NH2:27])[CH2:15][C:16]([P:22]([O-:25])([OH:24])=[O:23])([P:18]([OH:21])([OH:20])=[O:19])[OH:17].[Na+]>O>[CH2:14]([CH2:26][NH2:27])[CH2:15][C:16]([P:18]([OH:20])([OH:21])=[O:19])([P:22]([OH:25])([OH:24])=[O:23])[OH:17]

Komponenten

4

Edukt 2

HCID 24456Tricalcium PhosphateHCID 16760285Alendronate sodium anhydrous

Produkt 1

HCID 2088Alendronic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of calcium phosphate was prepared by introducing 100 mg of CDA into 8.75 ml of ultrapure water mixed with 1.25 ml of a 0.02 mol.l−1 sodium alendronate aqueous solution. The suspension was placed in a tube maintained at room temperature, and was stirred with a rotary stirrer at 16 rpm for 5 days. The suspension was then centrifuged and the most part of the supernatant was removed. The solid residue was filtered off, washed several times with small portions of ultrapure water, and then dried at room temperature. The resulting solid contained 7.4 wt % alendronate.

Aufarbeitung

  1. customwas prepared
  2. customThe suspension was placed in a tube
  3. customthe most part of the supernatant was removed
  4. filtrationThe solid residue was filtered off
  5. washwashed several times with small portions of ultrapure water
  6. customdried at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-d0464a26ba034fc48971c5617335d828
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889165B2

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