Maleic Acid → HCID 86633612, Verbindung

HRID 336390

Reaktionsgleichung

Reaktionsgleichung von HRID 336390
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C@@H:11]2[N:20]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][N:26]=3)[C:18](=[O:19])[C:13]3[N:14]=[CH:15][CH:16]=[N:17][C:12]2=3)=[O:9])[CH2:4][CH2:3]1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([OH:33])=[O:32]>C(O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C@@H:11]2[N:20]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][N:26]=3)[C:18](=[O:19])[C:13]3[N:14]=[CH:15][CH:16]=[N:17][C:12]2=3)=[O:9])[CH2:4][CH2:3]1.[C:28]([O-:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([O-:33])=[O:32]

Komponenten

4

Edukt 2

HCID 444266Maleic AcidHCID 969472Eszopiclone

Produkt 1

HCID 86633612HCID 86633612, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A reactor was charged with 0.101 g (S)-zopiclone and 0.040 g maleic acid. The mixture was charged with 18 g ethanol, and agitated. The slurry was heated to 60° C. and aged for 90 minutes. The slurry was cooled to 20° C. and aged for 60 minutes. The reaction was filtered, washed once with 0.5 g ethanol, dried in vacuo at approximately 50° C. for approximately 6 hr, and provided the titled compound in 76% yield.

Aufarbeitung

  1. temperatureThe slurry was cooled to 20° C. and aged for 60 minutes
  2. filtrationThe reaction was filtered
  3. washwashed once with 0.5 g ethanol
  4. customdried in vacuo at approximately 50° C. for approximately 6 hr

Quellen und Nachweise

ORD-Eintrag
ord-0e8edbadd5694c8bbb6637ad37f09fe7
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889685B2

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