4-Fluoro-2-nitrophenol → 2-Amino-4-fluorophenol

HRID 337329

Reaktionsgleichung

Reaktionsgleichung von HRID 337329
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:9]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[NH2:9][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[OH:8]

Komponenten

4

Edukt 1

HCID 1362364-Fluoro-2-nitrophenol

Produkt 1

HCID 27359172-Amino-4-fluorophenolAusbeute 86,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol, and 120 mg of 10% palladium/carbon was added and stirred under hydrogen atmosphere at room temperature for 1 hour. After the insoluble matter was filtered off, the filtrate was distilled off under reduced pressure to yield 211 mg of the title compound.

Aufarbeitung

  1. filtrationAfter the insoluble matter was filtered off
  2. distillationthe filtrate was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3bdbe08535b049f4b504bdb13705ee74
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889727B2

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