Ethanol → 1-(2-methoxyphenyl)-1H-pyrazole

HRID 337331

Reaktionsgleichung

Reaktionsgleichung von HRID 337331
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][NH2:11].O.[C:13](=O)([O-])[O-].[Na+].[Na+].[CH2:19](O)[CH3:20]>>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH:20]=[CH:19][CH:13]=[N:11]1

Komponenten

5

Edukt 4

HCID 702EthanolHCID 962WaterHCID 10340Sodium CarbonateHCID 28494452-Methoxyphenylhydrazine Hydrochloride

Produkt 1

HCID 112867471-(2-methoxyphenyl)-1H-pyrazole

Versuchsvorschrift

200 mg of 2-methoxyphenyl hydrazine hydrochloride was dissolved in 5 ml of ethanol, and 189 μl of malonaldehyde bisdimethylacetal was added and heated at reflux for 2 hours. To the reaction mixture was added 50 ml of water, neutralized with a saturated aqueous solution of sodium carbonate, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 179.4 mg of the title compound.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. extractionextracted with 60 ml of ethyl acetate
  4. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f40f54081c424eedbe16a9367a5ae4ae
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889727B2

Verknüpfte Notizen

Wird geladen…