Benzoyl Peroxide → 2-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

HRID 337619Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 337619
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].C1C(=O)N([Br:21])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:13][C:3]1[CH:4]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:6]=[CH:7][C:2]=1[Cl:1]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 22467254HCID 22467254, Verbindung

Produkt 1

HCID 591775552-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of 1-chloro-4-(2-methoxyethoxy)-2-methylbenzene (1 eq.) from the previous step, NBS (1.1 eq.) and benzoyl peroxide (0.05 eq.) in CCl4 (0.2 M) was refluxed for 2 h. The volatiles were then removed in vacuo and the resulting residue was suspended in hexanes. The insolubles were removed via filtration and washed further with hexanes. The filtrate was concentrated in vacuo to afford the title compound as a colorless oil.

Aufarbeitung

  1. temperaturewas refluxed for 2 h
  2. customThe volatiles were then removed in vacuo
  3. customThe insolubles were removed via filtration
  4. washwashed further with hexanes
  5. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-34047ed8e1f54db7a6d2fbe6d7aa3373
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889714B2

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