Bromine → HCID 178510531, Verbindung

HRID 33762

Reaktionsgleichung

Reaktionsgleichung von HRID 33762
[C:1]([CH:3]([C:7](=[S:25])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=2[Cl:23])=[C:11]([F:24])[CH:10]=1)[C:4]([NH2:6])=[O:5])#[N:2].BrBr>C(OCC)(=O)C>[Cl:23][C:17]1[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:16]=1[O:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:7]2[S:25][N:6]=[C:4]([OH:5])[C:3]=2[C:1]#[N:2])=[CH:10][C:11]=1[F:24]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 597977082-Cyano-2-[4-(2,5-dichloro-phenoxy)-3-fluoro-phenylthiocarbamoyl]-acetamide

Produkt 1

HCID 178510531HCID 178510531, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

2-Cyano-2-[4-(2,5-dichloro-phenoxy)-3-fluoro-phenylthiocarbamoyl]-acetamide (1.6 g, 4 mmol) was dissolved in anhydrous ethyl acetate (60 ml) and a solution of bromine (0.2 ml, 4 mmol) in anhydrous ethyl acetate (10 ml) was added dropwise into the mixture with stirring at room temperature. After addition, the reaction mixture was stirred for another 3 hours. The precipitate was filtered and the solid was washed with ethyl ether and suspended in a saturated sodium bicarbonate with stirring for 10 min. The solid was filtered, then washed with water and dried in vacuo to afford a white powder.

Aufarbeitung

  1. additionAfter addition
  2. stirringthe reaction mixture was stirred for another 3 hours
  3. filtrationThe precipitate was filtered
  4. washthe solid was washed with ethyl ether
  5. stirringwith stirring for 10 min
  6. filtrationThe solid was filtered
  7. washwashed with water
  8. customdried in vacuo
  9. customto afford a white powder

Quellen und Nachweise

ORD-Eintrag
ord-f298ca95d7054f29b2cf4adcb6a0640c
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429667B2

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