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Toluene → 2-(Tert-butyl)-6-aminophenanthridine

HRID 338183
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 338183
O1CCCOB1[C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[C:9]#[N:10].Br[C:16]1[CH:22]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:20]=[CH:19][C:17]=1[NH2:18].C([O-])([O-])=O.[K+].[K+].C1(C)C=CC=CC=1>[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(O)C>[C:23]([C:21]1[CH:22]=[CH:16][C:17]2[C:19](=[C:7]3[C:8](=[C:9]([NH2:10])[N:18]=2)[CH:11]=[CH:12][CH:13]=[CH:14]3)[CH:20]=1)([CH3:26])([CH3:24])[CH3:25]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 1140TolueneHCID 11430Potassium CarbonateHCID 2385912-Bromo-4-(tert-butyl)anilineHCID 35296022-(1,3,2-Dioxaborinan-2-yl)benzonitrile

Produkt 1

HCID 574376562-(Tert-butyl)-6-aminophenanthridineAusbeute 35,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 11979704
Tetrakis(triphenylphosphine)palladium
Katalysator
HCID 702EthanolLösungsmittel

Versuchsvorschrift

35.7 g (190 mmol) 2-(1,3,2-dioxaborinan-2-yl)benzonitrile, 31.9 g (158 mmol) 2-bromo-4-(tertbutyl)aniline, 3.6 g (3.16 mmol) tetrakis(triphenylphosphine) palladium(0) and 59.0 g (427 mmol) K2CO3 were heated to reflux in a 2 L flask containing 400 ml toluene and 300 mL ethanol. The reaction mixture was heated for 19 hours under constant N2 purge. HPLC of the reaction mixture indicated consumption of the starting aniline. The mixture was cooled and then filtered to remove the base. The base was washed with EtOAc to remove trace organic. The combined filtrate was evaporated down to give impure oil. The oil was purified on a column of silica using 95/5/0.05 CH2Cl2/MeOH/NH4OH as eluent to obtain separation. The product fractions were evaporated of solvent and the resultant residue recrystallized from CH2Cl2/hexanes to yield 14.0 g of the target compound as white solids (35.5% yield, confirmed by GC-MS).

Aufarbeitung

  1. temperatureto reflux in a 2 L flask
  2. temperatureThe reaction mixture was heated for 19 hours under constant N2
  3. custompurge
  4. customconsumption of the starting aniline
  5. temperatureThe mixture was cooled
  6. filtrationfiltered
  7. customto remove the base
  8. washThe base was washed with EtOAc
  9. customto remove trace organic
  10. customThe combined filtrate was evaporated down
  11. customto give impure oil
  12. customThe oil was purified on a column of silica using 95/5/0.05 CH2Cl2/MeOH/NH4OH as eluent
  13. customto obtain
  14. customseparation
  15. customThe product fractions were evaporated of solvent
  16. customthe resultant residue recrystallized from CH2Cl2/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-b5e1aadfa544403fbd279dcb5c764c14
Quelldatensatz
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08889864B2

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