4-Bromo-2-fluorobenzaldehyde → 4-Bromo-2-methoxybenzaldehyde

HRID 338516

Reaktionsgleichung

Reaktionsgleichung von HRID 338516
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:12][CH3:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 10942334Sodium Methoxide

Produkt 1

HCID 110530414-Bromo-2-methoxybenzaldehydeAusbeute 94,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-bromo-2-fluorobenzaldehyde (25.0 g, 0.123 mol) and sodium methoxide (13.99 g, 0.2600 mol) in dry methanol (250 mL) was stirred at reflux temperature for 16 hours. The mixture was concentrated and the residue was partitioned between dichloromethane (500 mL) and water (250 mL). The organic layers were combined and dried over sodium sulfate then concentrated in vacuo to provide the title compound as yellow solid (25 g, 94.5%).

Aufarbeitung

  1. temperatureat reflux temperature for 16 hours
  2. concentrationThe mixture was concentrated
  3. customthe residue was partitioned between dichloromethane (500 mL) and water (250 mL)
  4. dry with materialdried over sodium sulfate
  5. concentrationthen concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f10ddf9e31c6467c9c7d5611ebcdeb79
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889730B2

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