3,5-Dibromo-4-Hydroxybenzaldehyde → 2,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

HRID 338787

Reaktionsgleichung

Reaktionsgleichung von HRID 338787
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])[CH:5]=O.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1[SH:23]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[S:23][C:14]3[CH:15]=[CH:16][C:17]([C:19]([F:20])([F:21])[F:22])=[CH:18][C:13]=3[N:12]=2)[CH:7]=[C:8]([Br:11])[C:9]=1[OH:10]

Komponenten

4

Edukt 2

HCID 181003,5-Dibromo-4-HydroxybenzaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

Produkt 1

HCID 1361834942,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

In a N,N-dimethylformamide (DMF) solvent, a suspension of 3,5-dibromo-4-hydroxybenzaldehyde (1.0 eq.) and 2-amino-4-(trifluoromethyl)benzenethiol (1.0 eq.) was heated at a temperature of 100° C. After cooling, DMF was removed therefrom under reduced pressure. Methylene chloride was added to the resultant solid, and the produced precipitate was filtered, and washed with methylene chloride to obtain a solid target product.

Aufarbeitung

  1. temperatureAfter cooling
  2. customDMF was removed
  3. additionMethylene chloride was added to the resultant solid
  4. filtrationthe produced precipitate was filtered
  5. washwashed with methylene chloride
  6. customto obtain a solid target product

Quellen und Nachweise

ORD-Eintrag
ord-b681226bcc2444e1987d034dffcf3148
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889881B2

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