Ammonium Hydroxide → 6-Fluoro-2-methylquinolin-7-ol

HRID 338929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 338929
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12]C)[N:8]=[C:7]([CH3:14])[CH:6]=[CH:5]2.[NH4+].[OH-]>Br>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[N:8]=[C:7]([CH3:14])[CH:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 867074426-Fluoro-7-methoxy-2-methylquinoline

Produkt 1

HCID 1363380756-Fluoro-2-methylquinolin-7-olAusbeute 133,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 260Hydrogen BromideLösungsmittel

Versuchsvorschrift

6-Fluoro-7-methoxy-2-methylquinoline (5.2 g, 19 mmol) was heated to reflux in 48% aqueous HBr for 48 hours. After cooling, the reaction was basified (pH 8) by addition of NH4OH. The resulting solid was filtered, washed with water and dried to yield 6-fluoro-2-methylquinolin-7-ol (4.5 g, 93% yield) as a black solid.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationThe resulting solid was filtered
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-be71dbd7ade54710992c9e16f73af80b
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889704B2

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