Water → 7-Cyclopropyl-8-fluoro-2-methylquinoline

Reaktionsgleichung

Br[C:2]1[C:11]([F:12])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:13])=[N:9]2)=[CH:4][CH:3]=1.[Br-].[CH:15]1([Zn+])[CH2:17][CH2:16]1.C(OCC)(=O)C.O>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH:15]1([C:2]2[C:11]([F:12])=[C:10]3[C:5]([CH:6]=[CH:7][C:8]([CH3:13])=[N:9]3)=[CH:4][CH:3]=2)[CH2:17][CH2:16]1