Hydrochloric Acid → HCID 86653078, Verbindung

HRID 339131

Reaktionsgleichung

Reaktionsgleichung von HRID 339131
[O:1]=[C:2]([NH:22][CH:23]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=1)[C:24]([F:27])([F:26])[F:25])/[CH:3]=[CH:4]/[C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH:10]([NH:14]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2.Cl.O>O1CCOCC1>[NH2:14][CH:10]1[C:11]2[C:7](=[CH:6][C:5](/[CH:4]=[CH:3]/[C:2]([NH:22][CH:23]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:35])([F:36])[F:37])[CH:29]=3)[C:24]([F:25])([F:26])[F:27])=[O:1])=[CH:13][CH:12]=2)[CH2:8][CH2:9]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86653077tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

Produkt 1

HCID 86653078HCID 86653078, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2.2 g of tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate were dissolved in 40 ml of dioxane and admixed with 10 ml of semisaturated hydrochloric acid, and stirred at room temperature overnight. The reaction mixture was admixed with water and extracted with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and concentrated. This gave 1.5 g of (2E)-3-(1-amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}-acrylamide (82%).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic phases were dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-97bd1eda03cd4c65b483de5236d2ebf3
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889878B2

Verknüpfte Notizen

Wird geladen…