(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoic acid → tert-Butyl ((S)-3,3-dimethyl-1-((S)-7-nitro-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-1-oxobutan-2-yl)carbamate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoic acid	HCID 2734668	—
Edukt	(S)-tert-butyl 3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-7-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate	HCID 86705865	—
Edukt	(S)-7-Nitro-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide	HCID 86705890	—
Produkt	tert-Butyl ((S)-3,3-dimethyl-1-((S)-7-nitro-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-1-oxobutan-2-yl)carbamate	HCID 86705891	98%

Reaktionsschritte

Following a procedure analogous to that for the synthesis of Compound D, (S)-7-nitro-N—((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (1.69 g, 4.81 mmol) and (S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid (1.22 g, 5.29 mmol) were converted to the title compound (2.65 g, 98%). MS (ESI+) m/z 565.3 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08889712B2
Quelldatensatz	uspto-grants-2014_11
ORD ID	ord-83fa76593f0b40fd8232ecc024518a14
Quellennotiz	uspto-grants-2014_11