ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate → Ethyl 5-phenyl-1H-pyrrole-3-carboxylate

HRID 339726Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 339726
Cl[C:2]1[N:3](C)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]>CO.[Pd]>[C:12]1([C:4]2[NH:3][CH:2]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

4

Edukt 1

HCID 11832263ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate

Produkt 1

HCID 10242379Ethyl 5-phenyl-1H-pyrrole-3-carboxylateAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate (2.4 g, 9.1 mmol) and 10% Pd/C (100 mg) was dissolved in methanol (50 ml) at room temperature. The reaction mixture was hydrogenated for 6 hrs at room temperature and the resulting solution was filtered. After evaporated under reduced pressure, the residue was purified with normal phase preparative column chromatography to produce title compound (1.9g, 91%) as white solid.

Aufarbeitung

  1. filtrationthe resulting solution was filtered
  2. customAfter evaporated under reduced pressure
  3. customthe residue was purified with normal phase preparative column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-12bd385e253842538f585ceee5c28163
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895558B2

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