1-Isopropylpiperazine → HCID 178436930, Verbindung

HRID 340041

Reaktionsgleichung

Reaktionsgleichung von HRID 340041
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][C:13]3[NH:16][C:17]([C:19]4[C:27]5[C:22](=[CH:23][C:24]([C:28]6[CH:33]=[C:32]([F:34])[C:31]([OH:35])=[CH:30][C:29]=6[CH2:36][CH3:37])=[CH:25][CH:26]=5)[NH:21][N:20]=4)=[N:18][C:12]=3[CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH:38]([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)([CH3:40])[CH3:39]>>[CH2:36]([C:29]1[CH:30]=[C:31]([OH:35])[C:32]([F:34])=[CH:33][C:28]=1[C:24]1[CH:23]=[C:22]2[C:27]([C:19]([C:17]3[NH:16][C:13]4[CH2:14][CH2:15][N:10]([C:8]([C:5]5[N:6]=[CH:7][C:2]([N:44]6[CH2:45][CH2:46][N:41]([CH:38]([CH3:40])[CH3:39])[CH2:42][CH2:43]6)=[N:3][CH:4]=5)=[O:9])[CH2:11][C:12]=4[N:18]=3)=[N:20][NH:21]2)=[CH:26][CH:25]=1)[CH3:37]

Komponenten

3

Edukt 2

HCID 780131-IsopropylpiperazineHCID 178436919HCID 178436919, Verbindung

Produkt 1

HCID 178436930HCID 178436930, VerbindungAusbeute 19,2 %

Versuchsvorschrift

The title compound was prepared from (5-chloropyrazin-2-yl)(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (80 mg, 154 μmol) and 1-isopropyl-piperazine, (40 mg, 308 μmol) using the method of Example 32. The crude material was purified by HPLC Method D to afford (18 mg, 19%) of the title compound as off-white solid.

Aufarbeitung

  1. customThe crude material was purified by HPLC Method D

Quellen und Nachweise

ORD-Eintrag
ord-b11d2da0e28b499cb125f5dbae538a33
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895544B2

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