Water → 2-Bromo-5-fluoroanisole
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[C:10](=O)([O-])[O-].[K+].[K+].IC.O>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
10 g of 2-bromo-5-fluorophenol was dissolved in 105 mL of N,N-dimethylformamide, and added with 10.9 g of potassium carbonate and 4.9 mL of iodomethane under cooling, and stirred at room temperature for 3 hours. The reaction solution was added with water, extracted with diethyl ether, and the resultant organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated, to afford 9.75 g of the title compound as a yellow oil.
Aufarbeitung
- temperatureunder cooling
- extractionextracted with diethyl ether
- washthe resultant organic layer was washed with saturated brine
- dry with materialdried over magnesium sulfate
- customThe solvent was evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-45cd9a0160cb412a851ecc8da71ed727
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07429609B2
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