Acetic Acid → HCID 59797236, Verbindung

HRID 34034Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34034
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][N:8]2C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:4][C:3]=1[NH2:39].[C:40]([OH:43])(=O)[CH3:41]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][NH:8]2)=[CH:4][C:3]=1[NH:39][C:40](=[O:43])[CH3:41]

Komponenten

3

Edukt 2

HCID 176Acetic AcidHCID 68932237HCID 68932237, Verbindung

Produkt 1

HCID 59797236HCID 59797236, Verbindung

Versuchsvorschrift

525 mg of 6-fluoro-3-[(E)-2-(3-fluorophenyl)-vinyl]-1-trityl-1H-indazol-5-ylamine and 80 μl of glacial acetic acid were dehydraing-condensed in accordance with Example 127, followed by deprotection in the similar method as described in Example 16, to afford 150 mg of the title compound as bright yellow crystals.

Aufarbeitung

  1. customdehydraing-condensed in accordance with Example 127

Quellen und Nachweise

ORD-Eintrag
ord-63b07e23401b4d93b02ac0c3d93b842e
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

Notizen zur Reaktion

Wird geladen…