Water → HCID 59797368, Verbindung

HRID 34042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34042
[CH3:1][O:2][C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2.[OH2:22]>S(=O)(=O)(O)O>[CH3:1][O:2][C:3]1[C:11]([C:12]([NH2:13])=[O:22])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2

Komponenten

4

Edukt 2

HCID 962WaterHCID 59797311HCID 59797311, Verbindung

Produkt 1

HCID 59797368HCID 59797368, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

35 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carbonitrile was dissolved in a mixed solvent 2 mL concentrated sulfuric acid/1 mL water, and stirred at 110° C. for 1 hour and 15 minutes. After cooling the reaction mixture on ice, water was slowly poured under ice cooling, and the precipitated crystals were collected by filtration, and washed with water. After drying under reduced pressure, 22 mg of the title compound was obtained as brown crude crystals.

Aufarbeitung

  1. additionwas slowly poured under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customAfter drying under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-08e09919d2a84b068666e3fd16037872
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

Notizen zur Reaktion

Wird geladen…