(2,6-Dichlorophenyl)acetonitrile → 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 3408

Reaktionsgleichung

Reaktionsgleichung von HRID 3408
C(OCC[O-])C.[Na+].[Na].[NH2:9][C:10]1[N:15]=[C:14]([NH2:16])[C:13]([CH:17]=O)=[CH:12][N:11]=1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=1[CH2:27][C:28]#[N:29]>C(OCCO)C>[NH2:9][C:10]1[N:11]=[CH:12][C:13]2[CH:17]=[C:27]([C:21]3[C:20]([Cl:19])=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:26])[C:28]([NH2:29])=[N:16][C:14]=2[N:15]=1

Komponenten

6

Edukt 4

HCID 76678(2,6-Dichlorophenyl)acetonitrileHCID 3091762,4-Diaminopyrimidine-5-carbaldehydeHCID 5360545SodiumHCID 23667900Sodium 2-ethoxyethoxide

Produkt 1

HCID 53281136-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8076Glycol monoethyl etherLösungsmittel

Versuchsvorschrift

(Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture is heated at reflux for 4 hours, cooled, and the insoluble product washed with diethylether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine, mp 325-332° C. (MS).

Aufarbeitung

  1. custom(Prepared by the method of U.S
  2. temperatureThe mixture is heated
  3. temperatureat reflux for 4 hours
  4. temperaturecooled
  5. washthe insoluble product washed with diethylether

Quellen und Nachweise

ORD-Eintrag
ord-45783ee212a64703af0373922cf64354
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733913

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