Sodium Thiosulfate → HCID 178419485, Verbindung

HRID 34083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34083
[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1.[Br:10]N1C(=O)CCC1=O.S([O-])([O-])(=O)=S.[Na+].[Na+]>CN(C)C=O.C(OCC)(=O)C>[Br:10][C:3]1[C:4]2[CH:5]=[N:6][CH:7]=[CH:8][C:9]=2[NH:1][N:2]=1

Komponenten

6

Edukt 3

HCID 24477Sodium ThiosulfateHCID 67184N-bromobutanimideHCID 199305001H-Pyrazolo[4,3-c]pyridine

Produkt 1

HCID 178419485HCID 178419485, VerbindungAusbeute 73,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 3.85 g of 1H-pyrazolo[4,3-c]pyridine in 50 mL of N,N-dimethylformamide was added 6.04 g of N-bromosuccinimide at room temperature and stirred at this temperature for 2 hours. Adding 10 mL of 10% sodium thiosulfate aqueous solution, the solution was diluted with ethyl acetate. The organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 4.69 g of the title compound as pale red-brown crystals.

Aufarbeitung

  1. washThe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c33490b896594d5d9cb0c618ffaf0a57
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

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