Water → ethyl 5-bromo-2H-indazole-3-carboxylate

HRID 34093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34093
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.O.[C:20](OCC)(=O)[CH3:21]>C(O)C>[CH2:20]([O:12][C:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=2)[NH:7][N:6]=1)=[O:13])[CH3:21]

Komponenten

6

Edukt 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 8857Ethyl AcetateHCID 71573585-bromo-1H-indazole-3-carboxylic Acid

Produkt 1

HCID 12689364ethyl 5-bromo-2H-indazole-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3 g of 5-bromo-1H-indazole-3-carboxylic acid was dissolved in 60 mL of ethanol, added with 0.6 mL of concentrated sulfuric acid, and heated under reflux for 8 hours. After allowing to cool to room temperature, addition of water and extraction with ethyl acetate were conducted, and the resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine, dried over magnesium sulfate, and the solvent was evaporated, to afford 2.7 g of the title compound as yellow crystals.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. washthe resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d77850c85fd540af9825519a7b12cb14
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

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