C([O:3][C:4]([C:6]1([N:9]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH3:10])[CH2:8][CH2:7]1)=[O:5])C.O>CO.[OH-].[Na+]>[C:14]([O:13][C:11]([N:9]([CH3:10])[C:6]1([C:4]([OH:5])=[O:3])[CH2:8][CH2:7]1)=[O:12])([CH3:17])([CH3:16])[CH3:15]To a solution of 48 mg of 1-(tert-butoxycarbonyl-methyl-amino)-cyclopropane carboxylic acid ethyl ester in 0.4 mL of methanol, 0.1 mL of 5N sodium hydroxide aqueous solution was added and stirred at room temperature overnight. After adding water, the reaction solution was washed with diethyl ether. The aqueous layer was added with 0.7 mL of 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, to afford 36 mg of the title compound as white crystals.
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