Ethyl 3-(2-fluorophenyl)-3-oxopropanoate → 2,5-bis(2-fluorophenyl)-2,4-dihydro-3H-pyrazol-3-one

HRID 341043

Reaktionsgleichung

Reaktionsgleichung von HRID 341043
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][NH2:9].[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17](=O)[CH2:18][C:19](OCC)=[O:20]>C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:19](=[O:20])[CH2:18][C:17]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[F:10])=[N:9]1

Komponenten

4

Edukt 2

HCID 296342Ethyl 3-(2-fluorophenyl)-3-oxopropanoateHCID 4238442-Fluorophenylhydrazine hydrochloride

Produkt 1

HCID 671115152,5-bis(2-fluorophenyl)-2,4-dihydro-3H-pyrazol-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-Fluorophenyl hydrazine (1.26 g, 9.99 mmol) and ethyl 3-(2-fluorophenyl)-3-oxopropanoate (2.10 g, 9.99 mmol, 1 equiv) were combined in acetic acid (20 mL) and placed into an oil bath preheated at 120° C. for 3 hours. The mixture was cooled of ambient temperature and concentrated in vacuo. The residue was concentrated from toluene (3×50 mL), providing the titled compound.

Aufarbeitung

  1. customplaced into an oil bath
  2. concentrationconcentrated in vacuo
  3. concentrationThe residue was concentrated from toluene (3×50 mL)

Quellen und Nachweise

ORD-Eintrag
ord-a8496c9f34914093abd66b02a382dfcf
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895580B2

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