Acetic Anhydride → N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

HRID 34126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34126
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH2:16])=[C:11]([CH3:17])[CH:10]=1>>[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH:16][C:5](=[O:7])[CH3:6])=[C:11]([CH3:17])[CH:10]=1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 70180444-Bromo-5-fluoro-2-methylaniline

Produkt 1

HCID 23070217N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

Versuchsvorschrift

73.6 mL of acetic anhydride was added with 80.0 g of 4-bromo-5-fluoro-2-methylphenylamine at room temperature, and stirred at this temperature for 10 minutes. Excess acetic anhydride was distilled off under reduced pressure, and the precipitated crystals were washed with water, to afford 77.6 g of the title compound as colorless crystal.

Aufarbeitung

  1. distillationExcess acetic anhydride was distilled off under reduced pressure
  2. washthe precipitated crystals were washed with water

Quellen und Nachweise

ORD-Eintrag
ord-d239774155d24cce85ad6d774c49788d
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

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