Water → 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline

HRID 341737

Reaktionsgleichung

Reaktionsgleichung von HRID 341737
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12].O>CN(C)C=O>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[C:16]=1[C:17]([F:18])([F:19])[F:20]

Komponenten

5

Edukt 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 1455693-Amino-2-fluorobenzotrifluoride

Produkt 1

HCID 536697144-Bromo-2-fluoro-3-(trifluoromethyl)anilineAusbeute 76,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

A solution of N-bromosuccinimide (24.9 g) in N,N-dimethyl formamide was added to a solution of 2-fluoro-3-trifluoromethylaniline (25 g) in dimethyl formamide. The mixture was stirred for four and a half hours. It was poured into water and the oil was separated. The aqueous layers was extracted with ether and the combined organic layers were washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was distilled to give 4-bromo-2-fluoro-3-trifluoromethylaniline (27.44 g) as an orange oil, b.p. 88°-94° C./4 mbar.

Aufarbeitung

  1. customthe oil was separated
  2. extractionThe aqueous layers was extracted with ether
  3. washthe combined organic layers were washed with water
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customThe filtrate was evaporated to dryness
  7. distillationthe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-631dc0120bfa4282a8aa156e9f50f95d
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856274

Verknüpfte Notizen

Wird geladen…