Pyridine → 2-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester

HRID 341809

Reaktionsgleichung

Reaktionsgleichung von HRID 341809
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].C[CH:17](O)[C:18]([O-:20])=[O:19].N1C=CC=C[CH:23]=1>C(Cl)Cl>[S:3]([O:6][CH2:17][C:18]([O:20][CH3:23])=[O:19])([C:2]([F:15])([F:14])[F:1])(=[O:5])=[O:4]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 67749Trifluoromethanesulfonic anhydrideHCID 91435Lactate

Produkt 1

HCID 112297732-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl esterAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

10.09 ml (60 mmol) trifluorometansulfonic anhydrid dissolved in CH2Cl2 was added dropwise to a mixture of 4.05 ml (50 mmol) methylglycolate and 4.04 ml (50 mmol) pyridin in CH2Cl2 (totally 62.5 ml) at 0° C. during 25 minutes, and thereafter stirred at 0° C. for 1 H. After washing with 0.3M KHSO4 and saturated NA2CO3, drying (Na2SO4) and filtration, evaporation of the solvent in vacuo gave 9.94 g (90%) of the title compound.

Aufarbeitung

  1. washAfter washing with 0.3M KHSO4 and saturated NA2CO3
  2. customdrying
  3. filtration(Na2SO4) and filtration, evaporation of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ed848f084cb34979af6207996e646ec0
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856307

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