Pyridine → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine

HRID 341835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 341835
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([C:16](=O)[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.NO.[N:25]1C=CC=CC=1>C(O)C>[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([NH2:25])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 158384624,5-dihydro-2-(2-phenylethyl)-6H-imidazo[4,5,1-ij]-quinolin-6-one

Produkt 1

HCID 158384675,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A portion (16 g) of 4,5-dihydro-2-(2-phenylethyl)-6H-imidazo[4,5,1-ij]quinolin-6-one obtained in Example 1 was suspended in ethanol (160 mL) and hydroxylamine hydrochloride (8.06 g) and pyridine (14.1 mL) were added; following stirring for 17 hrs at room temperature, the precipitating crystals were collected by filtration and washed successively with ethanol and ether to yield the titled compound as colorless crystals (12.0 g).

Aufarbeitung

  1. filtrationthe precipitating crystals were collected by filtration
  2. washwashed successively with ethanol and ether

Quellen und Nachweise

ORD-Eintrag
ord-e6d91cb415d34892ab3fe755cc4b55d4
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856334

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