Butyl isocyanate → 1-Butyl-3-[7-(3-butyl-ureido)-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-2-yl]-urea

HRID 3419

Reaktionsgleichung

Reaktionsgleichung von HRID 3419
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH2:20])=[N:8][C:6]=2[N:7]=1.[CH2:21]([N:25]=[C:26]=[O:27])[CH2:22][CH2:23][CH3:24]>>[CH2:21]([NH:25][C:26]([NH:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH:20][C:26]([NH:25][CH2:21][CH2:22][CH2:23][CH3:24])=[O:27])=[N:8][C:6]=2[N:7]=1)=[O:27])[CH2:22][CH2:23][CH3:24]

Komponenten

3

Edukt 2

HCID 8110Butyl isocyanateHCID 53281136-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Produkt 1

HCID 218500281-Butyl-3-[7-(3-butyl-ureido)-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-2-yl]-urea

Versuchsvorschrift

A mixture of 0.5 g 2,7-Diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine from Example 1 and 15 mL of n-butyl isocyanate is refluxed for 2 hours. The reaction mixture is allowed to cool to room temperature and the insoluble material filtered. The solid is recrystallized several times from ethanol to give the title compound; mp 200°-202° C.

Aufarbeitung

  1. temperatureis refluxed for 2 hours
  2. filtrationthe insoluble material filtered
  3. customThe solid is recrystallized several times from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-53faf84c535e451092b026fc23418be8
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733913

Verknüpfte Notizen

Wird geladen…