Ammonia → 2-Aminoadenosine

HRID 341912

Reaktionsgleichung

Reaktionsgleichung von HRID 341912
[NH3:1].O.[C@@H:3]1([N:12]2[C:22]3[N:21]=[C:19]([NH2:20])[NH:18][C:16](=O)[C:15]=3[N:14]=[CH:13]2)[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]1[OH:5].Cl[Si](C)(C)C>O>[NH2:20][C:19]1[N:21]=[C:22]2[C:15]([N:14]=[CH:13][N:12]2[C@@H:3]2[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]2[OH:5])=[C:16]([NH2:1])[N:18]=1

Komponenten

5

Edukt 3

HCID 222Ammonia2×HCID 6397ChlorotrimethylsilaneHCID 135705230Guanosine Hydrate

Produkt 1

HCID 722002-Aminoadenosine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

This variation of the procedures of Robins, et al. supra, eliminated the need to utilize liquid ammonia in the reaction mixture since the ammonia molecule is generated in situ from the silazane reagent and the water of hydration of the guanosine hydrate starting material. Further, the use of chlorotrimethylsilane was not necessary nor was it necessary to conduct the reaction under anhydrous conditions, do a preliminary evaporation, or open and re-seal the Parr bomb under a dry nitrogen atmosphere.

Aufarbeitung

  1. customthe reaction under anhydrous conditions
  2. customa preliminary evaporation
  3. customopen and re-seal the Parr bomb under a dry nitrogen atmosphere

Quellen und Nachweise

ORD-Eintrag
ord-1cfcf0f15bc14dd4893523458c58b8b5
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856466

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