Ethyl Acetate → 1-(4-Bromo-phenyl)-isoquinolin-6-ol

HRID 342217

Reaktionsgleichung

Reaktionsgleichung von HRID 342217
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.C(OCC)(=O)C>C(O)(=O)C.Br>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 8857Ethyl AcetateHCID 111415351-(4-Bromo-phenyl)-6-methoxy-isoquinoline

Produkt 1

HCID 1361286691-(4-Bromo-phenyl)-isoquinolin-6-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 260Hydrogen BromideLösungsmittel

Versuchsvorschrift

The 1-(4-bromo-phenyl)-6-methoxy-isoquinoline obtained is boiled under reflux in 53 ml of acetic acid and 37 ml of 62% aqueous hydrobromic acid. Subsequently, after cooling to room temperature and addition of 150 ml of ethyl acetate the separated precipitate is filtered off. The crystals are washed with ethyl acetate and dried. There are obtained 7.6 g of 1-(4-bromo-phenyl)-isoquinolin-6-ol, MS: m/e 300 (M+H+, 1 Br).

Aufarbeitung

  1. filtrationis filtered off
  2. washThe crystals are washed with ethyl acetate
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-86d1d6104c494dc4936bdd7625021dfe
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856503

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