2-Propenoic acid, 2-methyl-3-phenyl- → alpha-Methylhydrocinnamic acid
Reaktionsgleichung
[CH3:1][C:2](=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]>CO.[Pd]>[CH3:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of α-methyl cinnamic acid (10.0 g., 61.7 mmol.) in dry methanol (250 ml.) was treated with 10% palladium on carbon and hydrogenated (balloon used) at room temperature for 16 hours. The reaction mixture was diluted with methanol (250 ml.), filtered through a Celite pad in a millipore unit, washing the pad well with methanol (2×100 ml.). The clear filtrate was evaporated to dryness to give 10.225 g. of title product as a thick syrup.
Aufarbeitung
- filtrationfiltered through a Celite pad in a millipore unit
- washwashing the pad well with methanol (2×100 ml.)
- customThe clear filtrate was evaporated to dryness
- customto give 10.225 g
Quellen und Nachweise
- ORD-Eintrag
- ord-aef57fa99f4e49468530852c0288a7a4
- Quelldatensatz
- uspto-grants-1999_01
- Patentnummer
- US05856476
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