4-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine → 1-[3-(Dimethylamino)propyl]piperazine

HRID 342503

Reaktionsgleichung

Reaktionsgleichung von HRID 342503
C(OC([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:22][N:20]([CH3:21])[CH2:19][CH2:18][CH2:17][N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1

Komponenten

4

Edukt 1

HCID 541555964-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine

Produkt 1

HCID 27362341-[3-(Dimethylamino)propyl]piperazineAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-benzyloxycarbonyl-3-dimethylaminopropylpiperazine (2.21 g, 7.2 mmol), 5% Pd/C (0.36 g) in methanol (20 ml) was stirred under hydrogen atmosphere at room temperature for 38 h. After removal of catalyst by Celite filtration, the filtrate was concentrated to afford 1.20 g (97.6%) of orange color viscous oil.

Aufarbeitung

  1. customAfter removal of catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-34838c0e87474c00b0147ee715122c4f
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05859011

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